Starting on December 1, the enhanced service will operate on a 98-seat E190 aircraft sourced from owner Connect Airways partner, Stobart Air.
The winter programme started on Sunday, October 27 and operates until March 28 2020.
In total, there are nine routes out of Edinburgh, operating up to 208 flights a week.
These include 24 flights a week to London City as well as a continuation of the sixth daily flight to Heathrow introduced in summer with the early morning flight departing Heathrow 06:40, arriving Edinburgh 08:15, and the evening flight returning to Heathrow from Edinburgh at 20:15, arriving 22:00.
In addition, there are up to seven flights a day to Birmingham; up to three a day to Manchester and up to four a day to Southampton.
The other routes operate to Belfast City, Cardiff, Exeter and Knock.
Flybe chief commercial officer Roy Kinnear said: “This winter, we are especially delighted to give those customers travelling with us to London City from Edinburgh an enhanced service by adding some jet services on this important business route at peak times.
“Our schedule is built around providing our customers with a wide choice of convenient travel options to the destinations they want. These include those that also offer lots of possible connections for onward travel both domestically and, through our many airline partners, to the rest of the world.