Lufthansa will resume its twice daily service from London City Airport to Frankfurt on 7 September.
The airport’s Head of Aviation Anne Doyere said this would mark a ‘significant milestone’ for London City and ‘a positive sign for the UK and Europe’s economic recovery’.
The flights will restore a connection between two of the world’s most important financial centres, she said.
“We have already seen demand from passengers to travel, especially for a summer holiday after months of lockdown,” she said.
“As restrictions continue to ease, with businesses increasing activity and more people getting back to work, we anticipate demand for business travel on routes such as this will grow as we head into the autumn.
“Lufthansa’s decision to resume this route with twice-daily flights demonstrates their confidence in that too.”
Ms Doyere said the airport was working with all of its airlines to re-establish other important and popular routes as soon as possible.